Dosing Guides

General principles

1. Start low. Begin at the bottom of the published range; you can always titrate up. The body's tolerance window for most peptides is wider than the effective window — find the floor that works for you.
2. Cycle. Most peptides should be used in 4–12 week cycles followed by a washout period. Continuous indefinite use erodes receptor sensitivity for many peptides (especially GH-axis).
3. Time of day matters. GH-axis peptides (ipamorelin, CJC-1295, sermorelin) are typically dosed at bedtime. Cognitive peptides (semax, selank) are typically morning. DSIP and other sleep-architecture peptides are dosed 30–60 minutes before sleep.
4. Fasted state for GH peptides. Two hours pre-injection and 30 minutes post-injection should be fasted to avoid blunting the pulse with insulin/somatostatin.
5. Track outcomes. Subjective scoring (PSQI for sleep, body composition for weight, joint pain VAS for recovery, etc.) plus objective labs every 6–8 weeks.
6. Pre-protocol bloodwork. For any protocol over 8 weeks: CMP, CBC, lipid panel, A1c, fasting insulin, IGF-1, prolactin, cortisol. Recheck at 6-week mark.

Reconstitution & storage

Most peptides arrive lyophilized (freeze-dried). Reconstitute with bacteriostatic water (BAC water) — never tap or distilled. Standard reconstitution: enough BAC water that 1 unit on an insulin syringe = your desired dose. Once reconstituted, refrigerate at 2–8°C and use within 14–30 days (peptide-specific; see product page). Do not freeze reconstituted peptide.

Resources

Read the full peptide dosing guide for a systematic overview. For peptide-by-peptide protocols, click any card above. For sourcing-quality considerations (COA reading, counterion content, etc.), see Trust & Safety.