Epitalon 5mg · Synthetic Tetrapeptide (Ala-Glu-Asp-Gly) · 99.1% Purity

What is Epitalon?

Epitalon (Epithalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed by Russian gerontologist Vladimir Khavinson, modeled on a natural peptide extracted from bovine pineal gland. It is the most-cited research peptide for telomerase activation and pineal-axis anti-aging research.

What is Epitalon used for?

Research applications include telomerase upregulation studies, melatonin-rhythm normalization, sleep architecture restoration in older subjects, and immunosenescence research. Khavinson's published longitudinal data on a Russian elderly cohort showed measurable longevity effects, though methodology has been debated. Often stacked with MOTS-c and NAD+ for compound longevity research and with Sermorelin for GH-axis pairing.

How does it work?

Synthetic tetrapeptide; upregulates telomerase, normalizes melatonin rhythm, and modulates pineal-gland function. Read our complete research hub for the full literature review, or jump to our best peptides for anti-aging article for comparator molecules.

Why this listing?

Epitalon is typically dosed in short pulse cycles (10–20 days) rather than continuously, mimicking the protocols used in Khavinson's original work. Aeon Labs' batch EPI-2604-E tested 99.1% pure by HPLC.

How Peptide.best sources and verifies Epitalon

Every Epitalon listing on Peptide.best comes from a verified vendor that has passed our onboarding audit — GMP-licensed manufacturing facility, documented chain of custody, third-party Janoshik Analytical testing on every batch, and a published Certificate of Analysis. Aeon Labs (the seller on this listing) currently maintains a 4.9-star average across all their products. Compare the five live offers on the right side of this page — Peptide.best forces vendors to compete on price and purity for the same SKU, so you always see the best current deal at the top, with the COA-verified purity, shipping speed, and seller rating side-by-side. Looking for alternatives in the same anti-aging space? MOTS-c and the other peptides listed under our Anti-Aging category are the most commonly compared alternatives.

Commonly stacked with

MOTS-c · NAD+ · Sermorelin · Thymosin Alpha-1. See the peptide stacks page for full protocol writeups.

Compliance notice

Epitalon has not been evaluated by the FDA for any indication. All statements on this page are based on published research and are not medical claims. Some products may be sold for research purposes only as marked. Consult a licensed healthcare provider before use. See our full disclaimer.

Research literature

Epitalon has been the subject of growing peer-reviewed and preclinical research across the anti-aging domain. The current PubMed index returns several hundred citations spanning mechanism, dose-response, and adverse-event reporting.

Key references commonly cited in Epitalon research:

• Mechanism papers covering synthetic tetrapeptide; upregulates telomerase, normalizes melatonin rhythm, and modulates pineal-gland function.
• Dose-response work in rodent models (most studied species)
• Comparator-molecule trials vs. MOTS-c and other peptides in the same class
• Safety / pharmacovigilance datasets where available

For a full reference list, see the Peptide.best Research Hub or the dedicated Anti-Aging pillar article.

Standard research dosing

Standard pulse protocol: 5–10 mg subcutaneous, daily, for 10–20 days; repeated 1–2x per year. Some intranasal protocols also documented.

Reconstitution

This product ships as lyophilized powder. Reconstitute with Bacteriostatic water (2mL) for stable refrigerated storage. Once reconstituted, use within 30 days; keep at 2–8°C.

Protocol notes

For full protocols and stacking guidance, see our peptide dosing guides. Always start at the low end of the published range and titrate based on individual response. Half-life (~30 min systemic; effects last weeks) determines dosing frequency.

Reported side effects

Extremely well-tolerated in all published work — no reports of significant adverse events at studied doses. Mild transient fatigue during loading reported anecdotally.

Contraindications

Do not use during pregnancy or lactation. Do not combine with other peptides without reviewing pharmacology. Consult a licensed healthcare provider before beginning any peptide research protocol. Discontinue immediately if any adverse reaction occurs and contact your provider.

Drug interactions

Limited interaction data exists for most research peptides. Be especially cautious when combining with prescription medications affecting the same physiological pathway as Epitalon (anti-aging pathway).

Certificate of Analysis

Every batch of Epitalon sold on Peptide.best ships with a third-party Certificate of Analysis (COA) from Janoshik Analytical — the most-cited independent peptide testing lab in the research community.

Current batch testing summary

• Batch ID: EPI-2604-E
• Test date: 04/14/2026
• Peptide content (HPLC): 99.1%
• Mass-spec identity: Confirmed (target mass match)
• Endotoxin (LAL): Below detection limit
• Residual solvents: Within USP <467> limits

Download full COA PDF

For our overall testing process and chain-of-custody details, see Trust & Safety.

Q: Is Epitalon legal to purchase?

A: Epitalon is sold on Peptide.best for research purposes where applicable. Legal status varies by jurisdiction. See our disclaimer for full details.

Q: How long until I see effects?

A: Timing depends on protocol, dose, and individual response. Most users report observable changes within 2–6 weeks of consistent dosing per the standard research protocols. See the Dosing & Protocol tab.

Q: Can I stack Epitalon with other peptides?

A: Yes — see commonly stacked peptides in the Overview tab, or browse our peptide stacks page for full protocol writeups.

Q: Why is the price lower than pharmacy retail or other research sites?

A: Peptide.best aggregates verified vendors and forces them to compete in a single checkout. Vendors save on customer-acquisition cost; the savings pass to you. Every batch is still 3rd-party COA tested.

About Aeon Labs

Aeon Labs is one of the six verified vendor partners on Peptide.best. They maintain a 4.9-star average rating across all products and submit every batch to third-party HPLC analysis before it ships.

All Aeon Labs products on Peptide.best ship from a GMP-licensed contract manufacturing facility and are tested by Janoshik Analytical. Cold-chain shipping is included on temperature-sensitive products.