Bioregulators, NAD+ precursors, GH secretagogues, and mitochondrial peptides. Built around Epitalon, NAD+, and Sermorelin — the three pillars of the modern longevity stack.
The Khavinson protocol's most-studied tetrapeptide. 99.6% purity, lab-tested. View product →
by Aeon Labs · ★ 4.9 (1,348 reviews)Khavinson tetrapeptide with documented telomerase-activating effects in cultured human cells and increased lifespan in rodent studies. The single most-cited longevity peptide. Typical protocol is 5–10 mg/day for 10 days, repeated quarterly. Cross-shops with sleep.
Direct NAD+ injection — tissue NAD+ declines ~50% between ages 20 and 60, and this cofactor sits at the center of every ATP-producing reaction. The longevity stack's energy pillar. Cross-shops heavily with energy buyers.
A 29-amino-acid GHRH analog that restores age-related declines in growth hormone amplitude. Pre-bed protocol stimulates the natural overnight pulse rather than introducing exogenous GH. The most physiological approach to age-related GH decline. Pairs with Ipamorelin.
Modified GHRH that extends growth-hormone pulse duration. Often stacked with Ipamorelin for the canonical longevity GH-replacement protocol. Most useful for buyers 35+ who want to restore deep-sleep GH amplitude.
Mitochondrial-DNA-encoded peptide that improves insulin sensitivity and glucose handling in published animal studies. Declines with age, replacement appears to restore metabolic flexibility. Stack partner with NAD+ for buyers building a longevity protocol.
Oral NNMT inhibitor. NNMT consumes the methyl donors that NAD+ pathways need; inhibiting it preserves cellular methylation capacity. The mechanistic rationale dovetails with NAD+ protocols. Oral format suits buyers avoiding injection.
"Anti-aging" is a fuzzy category, so we're going to be precise. The peptides in this list don't reverse aging — there is no published evidence that any of them do. What they do is target specific, measurable biomarkers that decline with age: telomere length, NAD+ concentration, growth-hormone pulse amplitude, mitochondrial function, and methylation capacity. The buyers most satisfied with results on this platform aren't chasing "youth"; they're chasing slower decline in specific biomarkers they actually track.
Epitalon (Ala-Glu-Asp-Gly) is the most-studied product of the Khavinson group, with peer-reviewed literature documenting telomerase activation in cultured human cells, increased lifespan in mice, and improved sleep-melatonin rhythm in aging humans. Typical protocol: 5–10 mg/day subcutaneous for 10 days, repeated quarterly. Many buyers sync this with their sleep protocol because Epitalon's pineal effect produces deeper sleep as a near-immediate side benefit.
NAD+ concentration declines roughly 50% between ages 20 and 60. Because NAD+ is required for every oxidative-phosphorylation ATP production and is consumed by sirtuin and PARP enzymes, low NAD+ shows up in nearly every age-related decline. NAD+ via subcutaneous injection achieves substantially higher tissue concentrations than oral NMN/NR precursors. Common loading protocol is 100 mg/day for 10 days, then weekly maintenance.
Growth-hormone amplitude declines steadily from peak adolescent levels. Restoring physiological GH amplitude (without exogenous GH itself) is one of the most measurable anti-aging interventions on the market. Sermorelin is the gentlest entry point — short half-life, mimics natural GHRH. CJC-1295 + Ipamorelin is the stronger stack, producing a pronounced first-third-of-night GH pulse. Either approach improves overnight tissue repair, body composition, and subjective recovery.
MOTS-c is a mitochondrial-DNA-encoded peptide that improves metabolic flexibility and exercise capacity in animal studies. Levels decline with age. Stack with NAD+ for the broadest mitochondrial coverage. 5-Amino-1MQ inhibits NNMT, preserving the methyl donors that NAD+ biosynthesis depends on — a complementary mechanism rather than a redundant one.
Across the longevity stack, the most commonly reported issues are: injection-site reactions, mild flushing (NAD+ if injected too fast), increased dream vividness (Epitalon), and elevated hunger (Ipamorelin). None of these peptides are FDA-approved for anti-aging indications. Always consult a licensed healthcare provider, particularly if you have a history of cancer (telomerase activation is an open theoretical concern with Epitalon), diabetes, or pituitary issues.
| Your priority | Start with | Why |
|---|---|---|
| Build a foundational longevity stack | Epitalon + NAD+ | Telomere + cofactor coverage |
| Restore GH amplitude | Sermorelin | Gentle, most physiological |
| Aggressive GH protocol | CJC + Ipamorelin | Stronger pulse, established stack |
| Mitochondrial energy | MOTS-c + NAD+ | Cross-shops with energy |
| Avoid injection | 5-Amino-1MQ | Oral NNMT inhibitor |
Want the full deep-dive? Read our complete guide to anti-aging peptides with dosing schedules, biomarker tracking suggestions, and citations.
For most buyers, Epitalon is the cleanest first protocol — it's a defined 10-day cycle, low side-effect profile, and the perceived benefit (better sleep quality) is felt within the first cycle. From there, layer in NAD+ and one of the GH peptides depending on your goals.
Track objective biomarkers: blood NAD+ levels, IGF-1 (downstream of GH), DEXA body composition, and ideally an epigenetic-age clock test (DunedinPACE, GrimAge) at 6–12 month intervals. Subjective markers (sleep quality, energy, recovery) help but are easily confounded.
Telomerase activators (Epitalon) and GH-axis peptides have theoretical proliferation-stimulating effects that should be discussed with a physician if you have a personal or family cancer history. There is no established human evidence of increased risk at the doses used here, but the theoretical signal is real and worth respecting.
Yes — the standard longevity stack runs Epitalon (cyclically), NAD+ (continuously), and a GH peptide (pre-bed). Start one at a time over a 30–60 day window so you can attribute effects and side effects properly before stacking.