PT-141 10mg · Bremelanotide (MC3R/MC4R Agonist) · 99.0% Purity

What is PT-141?

PT-141 (bremelanotide) is the FDA-approved selective MC3R/MC4R agonist sold under the brand Vyleesi. By skipping MC1R activity (the pigmentation receptor), PT-141 produces the same central libido response as its parent Melanotan II without the tanning side effects.

What is PT-141 used for?

PT-141 is the most-studied peptide for hypoactive sexual desire disorder (HSDD) in pre-menopausal women — the indication for which Vyleesi was approved. Research also covers male erectile response (PDE5-inhibitor non-responders), central arousal mechanisms, and cognitive dopamine pathway research. Stack research with Selank for anxiety-modulation co-protocols is published.

How does it work?

Selective MC3R/MC4R agonist (no MC1R activity); activates central libido pathways without affecting pigmentation. Read our complete research hub for the full literature review, or jump to our best peptides for libido article for comparator molecules.

Why this listing?

Onset is typically 45–75 minutes post-injection, peak effect at 2–3 hours. Vanta Bio's PT-141 batch PT1-2604-B tested 99.0% pure by HPLC with mass-spec identity confirmation.

How Peptide.best sources and verifies PT-141

Every PT-141 listing on Peptide.best comes from a verified vendor that has passed our onboarding audit — GMP-licensed manufacturing facility, documented chain of custody, third-party Janoshik Analytical testing on every batch, and a published Certificate of Analysis. Vanta Bio (the seller on this listing) currently maintains a 4.8-star average across all their products. Compare the five live offers on the right side of this page — Peptide.best forces vendors to compete on price and purity for the same SKU, so you always see the best current deal at the top, with the COA-verified purity, shipping speed, and seller rating side-by-side. Looking for alternatives in the same libido space? Melanotan II and the other peptides listed under our Libido category are the most commonly compared alternatives.

Commonly stacked with

Melanotan II · Ipamorelin · Selank · Semax. See the peptide stacks page for full protocol writeups.

Compliance notice

PT-141 has not been evaluated by the FDA for any indication. All statements on this page are based on published research and are not medical claims. Some products may be sold for research purposes only as marked. Consult a licensed healthcare provider before use. See our full disclaimer.

Research literature

PT-141 has been the subject of growing peer-reviewed and preclinical research across the libido domain. The current PubMed index returns several hundred citations spanning mechanism, dose-response, and adverse-event reporting.

Key references commonly cited in PT-141 research:

• Mechanism papers covering selective mc3r/mc4r agonist (no mc1r activity); activates central libido pathways without affecting pigmentation.
• Dose-response work in rodent models (most studied species)
• Comparator-molecule trials vs. Melanotan II and other peptides in the same class
• Safety / pharmacovigilance datasets where available

For a full reference list, see the Peptide.best Research Hub or the dedicated Libido pillar article.

Standard research dosing

Approved adult dose (Vyleesi): 1.75 mg subcutaneous, on-demand, at least 45 minutes before activity. Research protocols sometimes use 0.5–2 mg ranges. Maximum 8 doses per month.

Reconstitution

This product ships as lyophilized powder. Reconstitute with Bacteriostatic water (2mL) for stable refrigerated storage. Once reconstituted, use within 30 days; keep at 2–8°C.

Protocol notes

For full protocols and stacking guidance, see our peptide dosing guides. Always start at the low end of the published range and titrate based on individual response. Half-life (~2.7 hours) determines dosing frequency.

Reported side effects

Most-common: nausea (~40% in trials), flushing, headache, transient blood-pressure elevation (4–6 mmHg systolic). Not for use with uncontrolled hypertension.

Contraindications

Do not use during pregnancy or lactation. Do not combine with other peptides without reviewing pharmacology. Consult a licensed healthcare provider before beginning any peptide research protocol. Discontinue immediately if any adverse reaction occurs and contact your provider.

Drug interactions

Limited interaction data exists for most research peptides. Be especially cautious when combining with prescription medications affecting the same physiological pathway as PT-141 (libido pathway).

Certificate of Analysis

Every batch of PT-141 sold on Peptide.best ships with a third-party Certificate of Analysis (COA) from Janoshik Analytical — the most-cited independent peptide testing lab in the research community.

Current batch testing summary

• Batch ID: PT1-2604-B
• Test date: 04/14/2026
• Peptide content (HPLC): 99.0%
• Mass-spec identity: Confirmed (target mass match)
• Endotoxin (LAL): Below detection limit
• Residual solvents: Within USP <467> limits

Download full COA PDF

For our overall testing process and chain-of-custody details, see Trust & Safety.

Q: Is PT-141 legal to purchase?

A: PT-141 is sold on Peptide.best for research purposes where applicable. Legal status varies by jurisdiction. See our disclaimer for full details.

Q: How long until I see effects?

A: Timing depends on protocol, dose, and individual response. Most users report observable changes within 2–6 weeks of consistent dosing per the standard research protocols. See the Dosing & Protocol tab.

Q: Can I stack PT-141 with other peptides?

A: Yes — see commonly stacked peptides in the Overview tab, or browse our peptide stacks page for full protocol writeups.

Q: Why is the price lower than pharmacy retail or other research sites?

A: Peptide.best aggregates verified vendors and forces them to compete in a single checkout. Vendors save on customer-acquisition cost; the savings pass to you. Every batch is still 3rd-party COA tested.

About Vanta Bio

Vanta Bio is one of the six verified vendor partners on Peptide.best. They maintain a 4.8-star average rating across all products and submit every batch to third-party HPLC analysis before it ships.

All Vanta Bio products on Peptide.best ship from a GMP-licensed contract manufacturing facility and are tested by Janoshik Analytical. Cold-chain shipping is included on temperature-sensitive products.