TB-500 5mg · Thymosin Beta-4 (fragment 17-23) · 99.0% Purity

What is TB-500?

TB-500 is a synthetic 23-amino-acid fragment of the naturally occurring Thymosin Beta-4 protein. It functions as an actin-sequestering peptide, promoting cell migration, capillary formation, and accelerated tissue regeneration across muscle, tendon, ligament, and skin compartments.

What is TB-500 used for?

Researchers commonly use TB-500 for systemic recovery from soft-tissue strain, chronic tendon issues (joint research), and post-surgical healing. It is frequently stacked with BPC-157 — the two peptides act on complementary repair pathways (TB-500 systemically, BPC-157 locally) for what the recovery research community calls the 'wolverine stack.'

How does it work?

Thymosin Beta-4 fragment; upregulates actin sequestration, promotes cell migration and capillary formation for systemic repair. Read our complete research hub for the full literature review, or jump to our best peptides for recovery article for comparator molecules.

Why this listing?

Unlike BPC-157, TB-500's effects are durable for 1–2 weeks per injection due to a long systemic half-life, which is why most protocols dose weekly rather than daily. Vanta Bio's batches are tested by Janoshik for endotoxin, peptide identity, and net mass.

How Peptide.best sources and verifies TB-500

Every TB-500 listing on Peptide.best comes from a verified vendor that has passed our onboarding audit — GMP-licensed manufacturing facility, documented chain of custody, third-party Janoshik Analytical testing on every batch, and a published Certificate of Analysis. Vanta Bio (the seller on this listing) currently maintains a 4.8-star average across all their products. Compare the five live offers on the right side of this page — Peptide.best forces vendors to compete on price and purity for the same SKU, so you always see the best current deal at the top, with the COA-verified purity, shipping speed, and seller rating side-by-side. Looking for alternatives in the same recovery space? BPC-157 and the other peptides listed under our Recovery category are the most commonly compared alternatives.

Commonly stacked with

BPC-157 · MGF · IGF-1 LR3 · GHK-Cu. See the peptide stacks page for full protocol writeups.

Compliance notice

TB-500 has not been evaluated by the FDA for any indication. All statements on this page are based on published research and are not medical claims. Some products may be sold for research purposes only as marked. Consult a licensed healthcare provider before use. See our full disclaimer.

Research literature

TB-500 has been the subject of growing peer-reviewed and preclinical research across the recovery domain. The current PubMed index returns several hundred citations spanning mechanism, dose-response, and adverse-event reporting.

Key references commonly cited in TB-500 research:

• Mechanism papers covering thymosin beta-4 fragment; upregulates actin sequestration, promotes cell migration and capillary formation for systemic repair.
• Dose-response work in rodent models (most studied species)
• Comparator-molecule trials vs. BPC-157 and other peptides in the same class
• Safety / pharmacovigilance datasets where available

For a full reference list, see the Peptide.best Research Hub or the dedicated Recovery pillar article.

Standard research dosing

Standard research protocols dose 2–5 mg per week, often split into 2 doses, for a 4–6 week loading phase followed by a maintenance dose every 2 weeks.

Reconstitution

This product ships as lyophilized powder. Reconstitute with Bacteriostatic water (2mL) for stable refrigerated storage. Once reconstituted, use within 30 days; keep at 2–8°C.

Protocol notes

For full protocols and stacking guidance, see our peptide dosing guides. Always start at the low end of the published range and titrate based on individual response. Half-life (~2-3 hours systemic; effects 1-2 weeks) determines dosing frequency.

Reported side effects

Reported side effects in research literature are minimal — occasional injection-site flushing, transient fatigue at high loading doses. No reports of organ toxicity at therapeutic ranges.

Contraindications

Do not use during pregnancy or lactation. Do not combine with other peptides without reviewing pharmacology. Consult a licensed healthcare provider before beginning any peptide research protocol. Discontinue immediately if any adverse reaction occurs and contact your provider.

Drug interactions

Limited interaction data exists for most research peptides. Be especially cautious when combining with prescription medications affecting the same physiological pathway as TB-500 (recovery pathway).

Certificate of Analysis

Every batch of TB-500 sold on Peptide.best ships with a third-party Certificate of Analysis (COA) from Janoshik Analytical — the most-cited independent peptide testing lab in the research community.

Current batch testing summary

• Batch ID: TB5-2604-B
• Test date: 04/14/2026
• Peptide content (HPLC): 99.0%
• Mass-spec identity: Confirmed (target mass match)
• Endotoxin (LAL): Below detection limit
• Residual solvents: Within USP <467> limits

Download full COA PDF

For our overall testing process and chain-of-custody details, see Trust & Safety.

Q: Is TB-500 legal to purchase?

A: TB-500 is sold on Peptide.best for research purposes where applicable. Legal status varies by jurisdiction. See our disclaimer for full details.

Q: How long until I see effects?

A: Timing depends on protocol, dose, and individual response. Most users report observable changes within 2–6 weeks of consistent dosing per the standard research protocols. See the Dosing & Protocol tab.

Q: Can I stack TB-500 with other peptides?

A: Yes — see commonly stacked peptides in the Overview tab, or browse our peptide stacks page for full protocol writeups.

Q: Why is the price lower than pharmacy retail or other research sites?

A: Peptide.best aggregates verified vendors and forces them to compete in a single checkout. Vendors save on customer-acquisition cost; the savings pass to you. Every batch is still 3rd-party COA tested.

About Vanta Bio

Vanta Bio is one of the six verified vendor partners on Peptide.best. They maintain a 4.8-star average rating across all products and submit every batch to third-party HPLC analysis before it ships.

All Vanta Bio products on Peptide.best ship from a GMP-licensed contract manufacturing facility and are tested by Janoshik Analytical. Cold-chain shipping is included on temperature-sensitive products.